Razorlight, Annie Lennox, Peter Gabriel and Rihanna were among more than 20 stars who took to the stage at the Ellis Park stadium in Johannesburg.
"It is still alarming that for every person who receives treatment there are four others that are newly infected" - Nelson Mandela
The event was organised by Mr Mandela's 46664 campaign to stand up against the scourge of Aids.
Under the guidance of the former apartheid prisoner, 46664 is a campaign to raise awareness of the global HIV/Aids pandemic.
It also aim to raise funds to support HIV/Aids projects throughout sub-Saharan Africa where the disease is rife.
"It is still alarming that for every person who receives treatment there are four others that are newly infected," Mr Mandela told the crowd.
"We are pleased to say that the 46664 prevention campaign is being stepped up and going from strength to strength."
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